NUPLAZID® (pimavanserin) is indicated for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.

NUPLAZID Resource
Library

Helpful tools for you, your patients, and their caregivers

For Healthcare Providers

Open laptop displaying Acadia Pharmaceuticals HCP Sample Portal login screen to order prescription samples and manage orders

HCP Sample Portal

Order samples and manage orders.

Form with "PDF" and a download arrow representing NUPLAZID treatment form available to download and complete

Treatment & Service Request Form

Download and complete this form to prescribe NUPLAZID and enroll your patient in Acadia Connect.

Guide with "PDF" and download arrow representing Getting Started on NUPLAZID® Brochure available for download

Getting Started on NUPLAZID Brochure

Download this brochure for information on dosing and administration, prescribing NUPLAZID, and Acadia Connect.

Proposed Mechanism of Action for NUPLAZID

Watch this video to learn about the proposed mechanism of action for NUPLAZID. The precise mechanism of action of NUPLAZID in the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis is unclear.

For Long-Term Care Facilities

Form with "PDF" and a download arrow shows NUPLAZID® Long-Term Care Service Request form available to download

Treatment & Service Request Form

Download and complete this form to prescribe NUPLAZID and enroll your resident in Acadia Connect.

Papers with "PDF" and a download arrow show NUPLAZID® Distribution Fact Sheet PDF available to download

Distribution Fact Sheet

Provides a product overview of NUPLAZID, including administration, storage, and handling; lists the available fulfillment options for your facility when placing an order.

Guide with "PDF" and a download arrow representing getting started on NUPLAZID® long-term care brochure available to download

Getting Started on NUPLAZID Long-Term Care Brochure

Download this brochure for information on dosing and administration, prescribing NUPLAZID, and Acadia Connect.

For Patients and Caregivers

Papers with "PDF" and a download arrow show Disease Education Fact Sheet PDF available to download

Disease Education Fact Sheet

Designed to give your patients an overview of PD psychosis.

Brochure with "PDF" and a download arrow shows NUPLAZID® Patient Brochure PDF available to download

Patient Brochure

Designed to give your patients and their caregivers more detailed information about NUPLAZID.

Patient Video: John Cwik

John talks about living with Parkinson’s disease psychosis and his experience with NUPLAZID.

IMPORTANT SAFETY INFORMATION and INDICATION

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS

  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
  • NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.
  • Contraindication: NUPLAZID is contraindicated in patients with a history of a hypersensitivity reaction to pimavanserin or any of its components. Rash, urticaria, and reactions consistent with angioedema (e.g., tongue swelling, circumoral edema, throat tightness, and dyspnea) have been reported.
  • Warnings and Precautions: QT Interval Prolongation

    • NUPLAZID prolongs the QT interval. The use of NUPLAZID should be avoided in patients with known QT prolongation or in combination with other drugs known to prolong QT interval (e.g., Class 1A antiarrhythmics, Class 3 antiarrhythmics, certain antipsychotics or antibiotics).

    • NUPLAZID should also be avoided in patients with a history of cardiac arrhythmias, as well as other circumstances that may increase the risk of the occurrence of torsade de pointes and/or sudden death, including symptomatic bradycardia, hypokalemia or hypomagnesemia, and presence of congenital prolongation of the QT interval.

  • Adverse Reactions: The adverse reactions (≥2% for NUPLAZID and greater than placebo) were peripheral edema (7% vs 2%), nausea (7% vs 4%), confusional state (6% vs 3%), hallucination (5% vs 3%), constipation (4% vs 3%), and gait disturbance (2% vs <1%).

  • Drug Interactions:

    • Coadministration with strong CYP3A4 inhibitors increases NUPLAZID exposure. Reduce NUPLAZID dose to 10 mg taken orally as one tablet once daily.

    • Coadministration with strong or moderate CYP3A4 inducers reduces NUPLAZID exposure. Avoid concomitant use of strong or moderate CYP3A4 inducers with NUPLAZID.

Indication NUPLAZID is indicated for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.

Dosage and Administration Recommended dose: 34 mg capsule taken orally once daily, without titration, with or without food.

NUPLAZID is available as 34 mg capsules and 10 mg tablets.

Please read the full Prescribing Information, including Boxed WARNING.